The PHD Comics has already presented this process as a game of Monopoly, but what will manifest all the intricacies in their visceral splendor is... making an RPG. Granted, it'll only appeal to a very small crowd, of which only a small fraction would be masochistic enough to relive their lives in an alternate reality.
But yes, it'd be a lot like Spore. The evolution and leveling-up through different stages, i.e. undergrad, grad, post-doc, (research associate), assistant prof, associate prof, full prof, and emeritus prof :-P
I suspect if anyone actually makes this game, it'd be more for self-amusement (abuse?) LOL.